| dc.identifier.uri | http://hdl.handle.net/11401/76978 | |
| dc.description.sponsorship | This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. | en_US |
| dc.format | Monograph | |
| dc.format.medium | Electronic Resource | en_US |
| dc.language.iso | en_US | |
| dc.publisher | The Graduate School, Stony Brook University: Stony Brook, NY. | |
| dc.type | Dissertation | |
| dcterms.abstract | Carbon nanotubes (CNTs) in recent years have been cited to provide great potential for biomedical applications such as drug delivery, imaging and hyperthermia. In particular, it has been shown that they are able to interact with a broad array of electromagnetic radiation, including microwaves. The latter is of great interest for cancer imaging and therapy due to its non-ionizing nature and unique balance of spatial resolution and penetration depth, as well as ability to thermally ablate tumor tissue. Combined with microwaves, CNTs can serve as a platform with high selectivity of microwave absorption, enabling selective microwave thermal therapy, and effective means for synergistically enhancing effect of radiotherapy, chemotherapy and immunotherapy in cancer treatment. However, impurities, poor dispersibility and lack of fine-tuning of intrinsic physicochemical properties hinder CNTs’ utility for these applications. We present a CNT formulation useful for such applications by investigating different purification methods and elucidating the impact of physicochemical changes on the microwave dielectric properties of CNT dispersions. Based on these results, we developed a formulation of CNTs with high dispersibility and microwave dielectric and heating properties by fine-tuning an acid purification method. We also performed in vivo acute toxicity and ultrasound and photoacoustic imaging of the CNTs after injecting directly into tumors of mice models to demonstrate safety and validate the ability of the CNTs to be monitored in real-time. This work brings CNTs closer to their potential to serve as microwave hyperthermia agents. | |
| dcterms.abstract | Carbon nanotubes (CNTs) in recent years have been cited to provide great potential for biomedical applications such as drug delivery, imaging and hyperthermia. In particular, it has been shown that they are able to interact with a broad array of electromagnetic radiation, including microwaves. The latter is of great interest for cancer imaging and therapy due to its non-ionizing nature and unique balance of spatial resolution and penetration depth, as well as ability to thermally ablate tumor tissue. Combined with microwaves, CNTs can serve as a platform with high selectivity of microwave absorption, enabling selective microwave thermal therapy, and effective means for synergistically enhancing effect of radiotherapy, chemotherapy and immunotherapy in cancer treatment. However, impurities, poor dispersibility and lack of fine-tuning of intrinsic physicochemical properties hinder CNTs’ utility for these applications. We present a CNT formulation useful for such applications by investigating different purification methods and elucidating the impact of physicochemical changes on the microwave dielectric properties of CNT dispersions. Based on these results, we developed a formulation of CNTs with high dispersibility and microwave dielectric and heating properties by fine-tuning an acid purification method. We also performed in vivo acute toxicity and ultrasound and photoacoustic imaging of the CNTs after injecting directly into tumors of mice models to demonstrate safety and validate the ability of the CNTs to be monitored in real-time. This work brings CNTs closer to their potential to serve as microwave hyperthermia agents. | |
| dcterms.available | 2017-09-20T16:51:35Z | |
| dcterms.contributor | Sitharaman, Balaji | en_US |
| dcterms.contributor | Button, Terry | en_US |
| dcterms.contributor | Hagness, Susan. | en_US |
| dcterms.contributor | Vaska, Paul | en_US |
| dcterms.creator | Xie, Shawn | |
| dcterms.dateAccepted | 2017-09-20T16:51:35Z | |
| dcterms.dateSubmitted | 2017-09-20T16:51:35Z | |
| dcterms.description | Department of Biomedical Engineering | en_US |
| dcterms.extent | 99 pg. | en_US |
| dcterms.format | Application/PDF | en_US |
| dcterms.format | Monograph | |
| dcterms.identifier | http://hdl.handle.net/11401/76978 | |
| dcterms.issued | 2016-12-01 | |
| dcterms.language | en_US | |
| dcterms.provenance | Made available in DSpace on 2017-09-20T16:51:35Z (GMT). No. of bitstreams: 1
Xie_grad.sunysb_0771E_12976.pdf: 2287350 bytes, checksum: b58178618cff09d6922b64f9ce7798dc (MD5)
Previous issue date: 1 | en |
| dcterms.publisher | The Graduate School, Stony Brook University: Stony Brook, NY. | |
| dcterms.subject | Biomedical engineering | |
| dcterms.subject | ablation, cancer, carbon nanotubes, hyperthermia, local delivery, microwave | |
| dcterms.title | Carbon Nanotubes as Localized Microwave Hyperthermia Agents | |
| dcterms.type | Dissertation | |
