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A CORRELATED BEHAVIORAL AND BIOCHEMICAL ANALYSIS INVESTIGATING GONADAL INFLUENCE ON PREFRONTAL CORTICAL FUNCTION THROUGH MODULATION OF NMDA RECEPTOR TRAFFICKING

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dc.contributor.advisor Kritzer, Mary F. en_US
dc.contributor.author Bhamidipaty, Surya en_US
dc.contributor.other Department of Biochemistry and Cell Biology en_US
dc.date.accessioned 2013-05-22T17:34:11Z
dc.date.accessioned 2015-04-24T14:46:13Z
dc.date.available 2013-05-22T17:34:11Z
dc.date.available 2015-04-24T14:46:13Z
dc.date.issued 2011-12-01
dc.identifier Bhamidipaty_grad.sunysb_0771M_10767 en_US
dc.identifier.uri http://hdl.handle.net/1951/59581 en_US
dc.identifier.uri http://hdl.handle.net/11401/71156 en_US
dc.description 45 pg. en_US
dc.description.abstract Neuronal activity in the prefrontal cortex (PFC) underlies working memory processes in the brain. Reports have suggested critical roles for gonadal steroid modulation of this PFC function in adult male rats (Kritzer et al 2007), yet the exact mechanisms have yet to be defined. Given the clinical implications of male PFC vulnerability with schizophrenia, this is an important question to be addressed. This thesis seeks to gain insight as to whether hormone control over NMDA-receptor mediated glutamate signaling may be part of the way hormones influence the PFC's complex operations. This will be accomplished in interrelated studies using gonadally intact control and gonadectomized male rats. First, Barnes Maze behavioral testing for spatial working memory recently shown to be impaired in gonadectomized (GDX) rats, will be used to determine whether a behavioral rescue in subjects can be ascertained by locally blocking NMDA receptors using (2R)-amino-5-phosphonopentanoate (APV, an NMDA antagonist) within the PFC. Complementary studies will evaluate the subcellular distribution profiles for the NR1 subunit of the NMDA receptor in PFC of control (SHAM) and GDX rats. In both studies, overexpression/overactivity of NMDA receptors at PFC synapses is expected in GDX relative to control rats. To date, the data collected indeed support the hypotheses that reduction of NMDA over-activity via APV in GDX restores PFC-dependent behaviors depicted by an enrichment of NR1 proteins at the membrane and at synapses in GDX PFC relative to controls. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Neurosciences--Biochemistry en_US
dc.subject.other Barnes Maze, gonadectomy, NMDA receptors, prefrontal cortex, schizophrenia, working memory en_US
dc.title A CORRELATED BEHAVIORAL AND BIOCHEMICAL ANALYSIS INVESTIGATING GONADAL INFLUENCE ON PREFRONTAL CORTICAL FUNCTION THROUGH MODULATION OF NMDA RECEPTOR TRAFFICKING en_US
dc.type Thesis en_US
dc.mimetype Application/PDF en_US
dc.contributor.committeemember Dean, Neta. en_US


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