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Synthesis of disulfide iron complexes

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dc.contributor.advisor Koch, Stephen A en_US
dc.contributor.author Tsai, Jung-Chu en_US
dc.contributor.other Department of Chemistry en_US
dc.date.accessioned 2013-05-22T17:35:43Z
dc.date.accessioned 2015-04-24T14:47:35Z
dc.date.available 2013-05-22T17:35:43Z
dc.date.available 2015-04-24T14:47:35Z
dc.date.issued 2011-12-01 en_US
dc.identifier Tsai_grad.sunysb_0771M_10800 en_US
dc.identifier.uri http://hdl.handle.net/1951/59895 en_US
dc.identifier.uri http://hdl.handle.net/11401/71443 en_US
dc.description 55 pg. en_US
dc.description.abstract Iron sulfur proteins are the most commonly known proteins in all living organisms. The active sites of some iron sulfur protein are clusters that are the polynuclear combinations of iron and sulfur atoms. Iron-sulfur clusters perform various biochemical abilities, for example, electron transfer. Iron-sulfur clusters can also act as redox and non-redox catalysts. Creating model metal centers which mimic the electronic configuration of the active sites and the interaction between proteins is still an issue today. We decided to design simple and benzene thiols that imitate the side arm of cysteine (-CH<sub>2</sub>-SH-). Therefore, we developed the H<sub>3</sub>PS3 series ligands, one of which is H<sub>3</sub>(PS3*). H<sub>3</sub>(PS3*) (Tris(3-phenyl-2-thiophenyl)phosphine) ligand contains three substituted phenyl rings that are expected to form iron complexes with different geometries because of steric effects. Through the reaction of Li<sub>3</sub>(PS3*) with Fe<super>II</super>Cl<sub>2</sub> H<sub>2</sub>O in acetonitrile, the neutral Fe(II) complex , [Fe<super>II</super>(PS3*)<sub>2</sub>], was obtained unexpectedly in the attempt to synthesize an Fe(II)Fe(II) dimeric complex. By studying the X-ray structure of [Fe<super>II</super>(PS3*)<sub>2</sub>] we suggest that the original Fe(II) ion was oxidized to Fe(III) by unknown reasons and thus Fe(II) is regenerated by the oxidative coupling of two (PS3*)<super>3-</super> ligands via the formation of two organic-disulfide bonds. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Chemistry en_US
dc.subject.other disulfide complex, iron en_US
dc.title Synthesis of disulfide iron complexes en_US
dc.type Thesis en_US
dc.mimetype Application/PDF en_US
dc.contributor.committeemember Lauher, Joseph W en_US
dc.contributor.committeemember Aubrecht, Katherine B en_US

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