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Impact of Early Life Stress and 5-HTTLPR on Adulthood Stress Reactivity: Investigation of Changes in Cortisol, Gene Expression and DNA Methylation

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dc.contributor.advisor Canli, Turhan en_US
dc.contributor.author Duman, Elif Aysimi en_US
dc.contributor.other Department of Biopsychology en_US
dc.date.accessioned 2013-05-24T16:38:17Z
dc.date.accessioned 2015-04-24T14:47:46Z
dc.date.available 2013-05-24T16:38:17Z
dc.date.available 2015-04-24T14:47:46Z
dc.date.issued 2012-08-01
dc.identifier.uri http://hdl.handle.net/1951/60245 en_US
dc.identifier.uri http://hdl.handle.net/11401/71503 en_US
dc.description 119 pg. en_US
dc.description.abstract Early life stress (ELS) is considered one of the important risk factors for adulthood psychopathology and has been associated with impairments in stress response systems such as the Hypothalamic-Pituitary-Adrenal axis (HPA). Over the last decade, studies on Gene-Environment interactions (GxEs) also suggested moderation of this relationship by genetic factors, such as the serotonin transporter polymorphism (5-HTTLPR). Although there are many studies investigating these associations, the underlying biopsychosocial mechanisms are not yet clear. The aim of this dissertation is to identify some of these mechanisms through the use of intermediate phenotypes such as cortisol reactivity, stress-related gene expression and DNA methylation. Healthy Caucasian men were recruited from the Stony Brook University and surrounding communities for participating in an experimental session that involved completion of questionnaires, a life events interview and an acute psychosocial stress paradigm called the Trier Social Stress Test (TSST). Saliva and blood samples were collected for genotyping, cortisol, gene expression and DNA methylation analyses. Results indicate an interaction between ELS and 5-HTTLPR on cortisol reactivity to the TSST as well as differential expression and DNA methylation of the candidate genes. These results provide evidence for the impact of ELS and 5-HTTLPR on different intermediate phenotypes leading to altered stress reactivity in adulthood. Future studies with different gender, ethnicity and clinical groups would complement the results of this study and open up possibilities for behavioral and pharmacological interventions. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Psychobiology en_US
dc.subject.other cortisol, dna methylation, early life stress, gene expression, glucocorticoid receptor, serotonin transporter en_US
dc.title Impact of Early Life Stress and 5-HTTLPR on Adulthood Stress Reactivity: Investigation of Changes in Cortisol, Gene Expression and DNA Methylation en_US
dc.type Dissertation en_US
dc.mimetype Application/PDF en_US
dc.contributor.committeemember Anderson, Brenda en_US
dc.contributor.committeemember Moyer, Anne en_US
dc.contributor.committeemember Stone, Arthur. en_US

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