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A feasibility study on using supercritical fluid technology to develop a biomimetic 3D porous scaffold for bone tissue engineering

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dc.contributor.advisor Meng, Yizhi en_US
dc.contributor.author ZHANG, CHI en_US
dc.contributor.other Department of Materials Science and Engineering en_US
dc.date.accessioned 2013-05-22T17:35:55Z
dc.date.accessioned 2015-04-24T14:47:49Z
dc.date.available 2013-05-22T17:35:55Z
dc.date.available 2015-04-24T14:47:49Z
dc.date.issued 2010-12-01
dc.identifier Zhang_grad.sunysb_0771M_10285 en_US
dc.identifier.uri http://hdl.handle.net/1951/59937 en_US
dc.identifier.uri http://hdl.handle.net/11401/71525 en_US
dc.description 83 pg. en_US
dc.description.abstract ? The key to designing a suitable material for bone replacement is to mimic the mineral component and the microstructure of natural bone. The novel artificial bone scaffold should have good mechanical properties, high porosity, bioactivity, and controllable degradation kinetics. In this work, a three-dimensional scaffold based on a polymer phase consisting of only naturally- derived components (gelatin and cornstarch) and a mineral phase (hydroxyapatite (HA)) was produced using supercritical CO2 as the foaming agent. By setting the pressure of the supercritical CO2 at 2500 psi and the temperature at 35??C, 3-D porous scaffolds were successfully fabricated and no organic solvent was used in the entire process. The results show the amount of the cornstarch to have a direct effect on the porosity, in that, without cornstarch the scaffold could not be foamed (the total volume has not increased in this case). Pore size of the scaffolds was influenced by the HA concentration. We also investigated the effect of two different gelatin cross-linking agents (trisodium citrate and EDC/NHS) and different cross- linking methods (infusion and immersion) on degradation kinetics and supercritical CO2 foaming. The results show that EDC/NHS cross-linked samples (by the immersion method) lasted longest for about 7 days at 37??C in SBF. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Materials Science en_US
dc.subject.other Bone, Cornstarch, Gelatin, Hydroxyapatite, Supercritical Fluids en_US
dc.title A feasibility study on using supercritical fluid technology to develop a biomimetic 3D porous scaffold for bone tissue engineering en_US
dc.type Thesis en_US
dc.mimetype Application/PDF en_US
dc.contributor.committeemember Meng, Yizhi en_US
dc.contributor.committeemember Gersappe, Dilip en_US
dc.contributor.committeemember Hadjiargyrou, Michael. en_US

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