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Biomimetic Calcium Phosphate Coatings Synthesized by Electrochemical Deposition and Air Plasma Spray: Morphology, Composition and Bioactive Performance

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dc.contributor.advisor Weyant, Christopher en_US
dc.contributor.author Li, Ling en_US
dc.contributor.other Department of Materials Science and Engineering en_US
dc.date.accessioned 2017-09-20T16:50:01Z
dc.date.available 2017-09-20T16:50:01Z
dc.date.issued 2013-12-01 en_US
dc.identifier.uri http://hdl.handle.net/11401/76321 en_US
dc.description 147 pgs en_US
dc.description.abstract In this project, with the aim to develop bioactive biomimetic coatings for dental and orthopedic applications, calcium phosphate based coatings deposited by electrochemical deposition and plasma spray were investigated. Different combinations of process parameters were used to achieve coatings with various chemical compositions and morphologies. The obtained coating composition was investigated by energy dispersive X-ray spectroscopy and X-ray diffraction. The microstructure of the coatings were studied through scanning electron microscopy while the cytocompatibility and bioactivity of the strontium-doped calcium phosphate coatings were evaluated using bone cell culture using MC3T3-E1 osteoblast-like cells. A set of designed experiments were performed to study the process-product-performance relationship. The experimental results suggested that the properties of the coatings were dramatically impacted by process parameters during both of the air plasma spray and electrochemical deposition processes. For electrochemical deposition, the influences of different process parameters such as current density, concentration, temperature and pH value of the electrolyte as well as the dose of strontium were investigated. A thermodynamic model was built to describe the calcium phosphate deposition behaviors in this process, which enhanced the understanding of this process, provided the possibility to predict and tailor the properties of deposited coatings. As for air plasma sprayed calcium phosphate coating, the links between process parameters--> particle state--> coating properties --> performance were successfully built through process map strategy. It was found that current and total gas flow were the key process parameters in this process, which controlled in-flame particle state, the morphologies of single splats, and eventually coating properties such as coating's phase, microstructure as well as coating thickness and the bioactivities of the coatings. The in-vitro cell culture experiment indicated that coating morphology and composition had dramatic impact on the behaviors of the cells: faceted monetie produced by electrodeposition was the most suitable substrate for the attachment and growth of the cells, compared to smoother air plasma sprayed calcium phosphate coatings and electrochemical deposited needle-like hydroxyapatite. Furthermore, the incorporation of strontium into calcium phosphate coatings leaded to enhanced cell proliferation suggesting its potential benefits for improving the bioactivity of the calcium phosphate coatings. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Engineering en_US
dc.subject.other air plasma spray, biomimetic, calcium phosphate, coating, electrochemcial depostion, osteoblast en_US
dc.title Biomimetic Calcium Phosphate Coatings Synthesized by Electrochemical Deposition and Air Plasma Spray: Morphology, Composition and Bioactive Performance en_US
dc.type Dissertation en_US
dc.mimetype Application/PDF en_US
dc.contributor.committeemember Meng, Yizhi en_US
dc.contributor.committeemember Gersappe, Dilip en_US
dc.contributor.committeemember Miller, Lisa en_US

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