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Basic Study on Degradation of nHAP-PLGA-Collagen – A Novel Biopolymer

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dc.contributor.advisor Tannenbaum, Irena en_US
dc.contributor.author Ren, Liqiang en_US
dc.contributor.other Department of Materials Science and Engineering. en_US
dc.date.accessioned 2017-09-20T16:50:04Z
dc.date.available 2017-09-20T16:50:04Z
dc.date.issued 2016-12-01 en_US
dc.identifier.uri http://hdl.handle.net/11401/76342 en_US
dc.description 54 pg. en_US
dc.description.abstract Bone tissue engineering is a rapidly developing field of interest. Bone scaffold materials have several applications of great importance including the fostering of healthy bone tissue and the repair of bone defects both in-vivo and in-vitro. Ideal scaffolds should be biocompatible, biodegradable, and promote cellular interactions and tissue development, and possess proper mechanical and physical properties. nHAP-PLGA-Collagen is a novel synthesized block-polymer which has proved biocompatibility and mechanical properties. This thesis is focused on the degradation-controlling to fulfill the requirement of bone reconstruction and afterward digestion. The research focuses on internal and external factors which have effects on degradation time of nHAP-PLGA-Collagen. Internal factors include monomer ratio of D, L-lactide and glycolide monomers, porosity, and macro construction, which can modify the polymer. And external factors are temperature and pH impact the degradation of storage and during bone forming. In this thesis, nHAP-PLGA-Collagen block polymer has been characterized and been proven to have properties accounting for a bone scaffold material, including degradation adaptability. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Materials Science en_US
dc.subject.other biodegradable polymer, Bone scaffold, degradation en_US
dc.title Basic Study on Degradation of nHAP-PLGA-Collagen – A Novel Biopolymer en_US
dc.type Thesis en_US
dc.mimetype Application/PDF en_US
dc.contributor.committeemember Venkatesh, T. en_US
dc.contributor.committeemember Abdelaziz, Sherif. en_US


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