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Candida albicans Adenylyl cyclase – cAMP Pathway and Hyphal Growth

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dc.contributor.advisor Konopka, James B en_US
dc.contributor.advisor Neiman, Aaron en_US
dc.contributor.author Parrino, Salvatore Michael en_US
dc.contributor.other Department of Molecular and Cellular Biology en_US
dc.date.accessioned 2017-09-20T16:50:23Z
dc.date.available 2017-09-20T16:50:23Z
dc.date.issued 2015-05-01 en_US
dc.identifier.uri http://hdl.handle.net/11401/76480 en_US
dc.description 80 pgs en_US
dc.description.abstract The human opportunistic fungal pathogen Candida albicans can undergo a transition from budding to hyphal growth in response to host cues that promotes tissue invasion and dissemination through the host. Accompanying the morphogenic change is an upregulation of genes that promote virulence. Morphogenic switching and subsequent gene regulation are required for full virulence in the host and are an area of intense study. It has been shown that increased production of cAMP by Cyr1 Adenylyl cyclase can induce hyphal growth. Further, it was proposed that activation of Cyr1 and an increase in cAMP were necessary for all hyphal growth in C. albicans. The main evidence for this necessity is that cells lacking Adenylyl cyclase (cyr1Δ) fail to induce hyphal growth in response to most physiological inducers. This evidence is not conclusive as deletion of CYR1 severely affects cellular health. I have demonstrated that signaling through Cyr1 and cAMP are not required for hyphal morphogenesis or virulence gene induction. I propose that cAMP-independent pathways are responsible for much of the morphogenic and gene regulatory signals produced by physiological inducers. My findings shed light on hyphal signaling in Candida albicans and will aid in the identification of drug targets and the development of novel therapeutics. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Molecular biology en_US
dc.subject.other Adenylyl cyclase, cAMP, Candida albicans, hyphal growth, hyphal induction, pseudorevertants en_US
dc.title Candida albicans Adenylyl cyclase – cAMP Pathway and Hyphal Growth en_US
dc.type Dissertation en_US
dc.mimetype Application/PDF en_US
dc.contributor.committeemember van der Velden, Adrianus en_US
dc.contributor.committeemember Bliska, James en_US

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