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Thalamocortical Input to the Primary Visual Cortex

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dc.contributor.advisor Maffei, Arianna en_US
dc.contributor.advisor Matthews, Gary G. en_US
dc.contributor.author Kloc, Michelle en_US
dc.contributor.other Department of Neuroscience en_US
dc.date.accessioned 2017-09-20T16:50:42Z
dc.date.available 2017-09-20T16:50:42Z
dc.date.issued 2014-12-01
dc.identifier.uri http://hdl.handle.net/11401/76583 en_US
dc.description 137 pgs en_US
dc.description.abstract The lateral geniculate nucleus (LGN) is the region of the thalamus that innervates and relays sensory information to the primary visual cortex (V1). Thalamocortical (TC) input from the LGN drives the activity of V1, and underlies the health and function of the visual system. However, little is known about the synaptic properties of this input. LGN inputs innervate two layers, layer 4 (L4) and layer 6 (L6). This input has been examined functionally and anatomically, but the synaptic mechanisms of this input are poorly understood. The anatomy of the projection from the LGN to V1 encumbers the preparation of an acute thalamocortical slice, thus direct electrophysiological investigations of TC synapses onto V1 neurons have not been done. In this study, I use optogenetics to selectively activate TC terminals in an acute slice preparation containing V1 and recorded postsynaptic currents from V1 neurons to investigate TC synaptic properties. I show that TC inputs to V1 have layer-specific synaptic properties, organization, and experience dependence. I have shown that TC inputs to L4, which receives the largest LGN projection, have target cell-type specific properties which are mediated by distinct pre-and postsynaptic mechanisms. Finally, I have shown a novel mechanism of feedback from the V1 circuit onto TC synapses, which is mediated by presynaptic GABAA receptors on TC terminals. Taken together, these results outline mechanisms for TC activation of the V1 circuit. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Neurosciences en_US
dc.subject.other Lateral geniculate nucleus, Primary visual cortex, Thalamocortical en_US
dc.title Thalamocortical Input to the Primary Visual Cortex en_US
dc.type Dissertation en_US
dc.mimetype Application/PDF en_US
dc.contributor.committeemember Fontanini, Alfredo en_US
dc.contributor.committeemember Wollmuth, Lonnie en_US
dc.contributor.committeemember Nugent, Fereshteh en_US

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