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Topics in Statistical Physics: Protein Stability, Non-Equilibrium Thermodynamics, and Bibliometrics

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dc.contributor.advisor Dill, Ken A en_US
dc.contributor.author Hazoglou, Michael John en_US
dc.contributor.other Department of Physics en_US
dc.date.accessioned 2017-09-20T16:50:51Z
dc.date.available 2017-09-20T16:50:51Z
dc.date.issued 2016-12-01
dc.identifier.uri http://hdl.handle.net/11401/76642 en_US
dc.description 90 pgs en_US
dc.description.abstract This dissertation will cover three distinct topics of protein stability, non-equilibrium thermodynamics and scientometrics. In senescent organisms aging is correlated with oxidative damage of proteins. The damage done to proteins destabilizes them inhibiting their function. The implications of a simplified model based on side-chain modification of charged residues using Debye-Hȕckel theory will be presented. Short length and highly charged proteins are susceptible to destabilization from oxidative damage. Among these proteins already studied in aging several proteins fit this description of being short and highly charged. There is a noticeable enrichment of short-highly-charged proteins in categories of proteins known to be important in aging. Maximum Caliber (MaxCal) is a potential theory of non-equilibrium statistical mechanics. It will be shown how MaxCal is used to derive the Onsager reciprocal relations, Green-Kubo relations and Prigogines Principle and extend these relations beyond the near-equilibrium regime. The last topic is the citation and publication trends of papers and authors, respectively. A discussion of how pure-birth processes can be applied to understanding citation trends and how birth-processes can be used in classifying papers into different categories of performance. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Physics en_US
dc.subject.other bibliometrics, Entropy, non-equilibrium thermodynamics, Protein stability en_US
dc.title Topics in Statistical Physics: Protein Stability, Non-Equilibrium Thermodynamics, and Bibliometrics en_US
dc.type Dissertation en_US
dc.mimetype Application/PDF en_US
dc.contributor.committeemember Fernandez-Serra, Marivi en_US
dc.contributor.committeemember Metcalf, Harold J en_US
dc.contributor.committeemember Balazsi, Gabor en_US

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