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Influence of maturation on hypoxic ventilatory responses in P0-P30 neonatal rat in vivo

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dc.contributor.advisor Solomon, Irene C en_US
dc.contributor.advisor Acosta-Martinez, Maricedes en_US
dc.contributor.author Reid, Inefta M. en_US
dc.contributor.other Department of Physiology and Biophysics. en_US
dc.date.accessioned 2017-09-20T16:51:07Z
dc.date.available 2017-09-20T16:51:07Z
dc.date.issued 2015-08-01 en_US
dc.identifier.uri http://hdl.handle.net/11401/76752 en_US
dc.description 140 pg. en_US
dc.description.abstract Hypoxia is a common feature of many pathologies including but not limited to asthma, spinal cord injury, chronic obstructive sleep pulmonary disease, and sudden infant death syndrome (SIDS). Even though neuromodulatory effects mediated by maturation have been widely studied in other disciplines, such efforts have been lacking in the area of respiratory control. This dissertation is motivated by questions such as how does a known change in respiratory neurotransmitters manifest differently in the modulation of known respiratory output, especially in response to moderate, mild, and sever hypoxia. Aimed at understanding the characteristics and underlying mechanisms involved maturation of the hypoxic ventilator response in neonatal rats in vivo. Although a limited number of studies have been done on newborn rodents, the mechanisms responsible for long-term and short-term variability and complexity of these dynamics within the neural network during postnatal development is not yet well-studied. Understanding the characteristics and underlying mechanisms of neural plasticity is important to the study of respiratory control during normal physiology as well as pathological disorders. In our first aim we discovered that neonatal rats exhibit a higher likelihood of gasping and the duration of gasping and number of gasp also had a maturational trend as well. Most importantly the network complexity (organization) was reduced during gasping. In the second part of our study data demonstrated that acute intermittent hypoxia (AIH) elicited respiratory long-term facilitation (LTF). However unlike the traditional response to AIH in the developing rat respiratory LTF primarily took the form of an enhancement in burst frequency, although an increase in burst amplitude was seen in some rats. Insight gained from this work will highlight that a distinct group of neurotransmitters are responsible for the varying responses to hypoxia and that they also manifest as a developmental response to exhibiting a similar behavior from the neonatal rat. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Neurosciences en_US
dc.subject.other Development, Hypoxia, Long-term facilitation, Neuroscience, Rat, Sudden Infant Death Syndrome en_US
dc.title Influence of maturation on hypoxic ventilatory responses in P0-P30 neonatal rat in vivo en_US
dc.type Dissertation en_US
dc.mimetype Application/PDF en_US
dc.contributor.committeemember Collins, William en_US
dc.contributor.committeemember Wong-Riley, Margaret. en_US

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