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Topics in Yeast Sporulation

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dc.contributor.advisor Neiman, Aaron en_US
dc.contributor.author Singer, Patrick en_US
dc.contributor.other Department of Biochemistry and Cell Biology en_US
dc.date.accessioned 2017-09-20T16:51:23Z
dc.date.available 2017-09-20T16:51:23Z
dc.date.issued 2016-12-01
dc.identifier.uri http://hdl.handle.net/11401/76898 en_US
dc.description 39 pg. en_US
dc.description.abstract Yeast sporulation is the process by which yeast cells under limiting nutrient conditions are able to alter their nuclear division cycle from mitotic division to meiotic division, resulting in development of up to 4 spores per diploid cell. Spores are a hardy cell type that can survive until nutrient conditions improve. Under particularly severe conditions, sporulating cells only produce 2 spores, in an arrangement known as a non-sister dyad (NSD). NSDs contain the two spores with the youngest spindle pole bodies (SPBs), which are produced in meiosis II. The SPBs are the central nucleating point of prospore membranes. A scaffolding component of the SPB, Nud1, has been shown to be phosphorylated at several sites, and be integral to the proper selection of NSD’s during sporulation. I sought to test the hypothesis that Nud1 accumulates phosphorylations over time and this allows the cell to recognize the younger SPB’s by their relative lack of phosphorylation. In an additional experiment we investigated the unknown sporulation function of four related GATA transcription factors induced late in sporulation. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Biochemistry -- Cellular biology en_US
dc.subject.other NSD, nud1 en_US
dc.title Topics in Yeast Sporulation en_US
dc.type Thesis en_US
dc.mimetype Application/PDF en_US
dc.contributor.committeemember Luk, Ed. en_US

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