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Development of Iodinated Graphene Nanoplatelets through Redox Reaction for their Use as CT Contrast Agents

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dc.contributor.advisor Sitharaman, Balaji en_US
dc.contributor.advisor Button, Terry en_US
dc.contributor.author Gadgil, Aditi Parag en_US
dc.contributor.other Department of Biomedical Engineering. en_US
dc.date.accessioned 2017-09-20T16:51:36Z
dc.date.available 2017-09-20T16:51:36Z
dc.date.issued 2013-12-01 en_US
dc.identifier.uri http://hdl.handle.net/11401/76990 en_US
dc.description 57 pg. en_US
dc.description.abstract Iodinated organic compounds currently dominate the market of contrast media for CAT imaging. When these compounds have to be used in large quantities for multiple CAT scans, it can result in adverse effects ranging from mild to severe. Secondly, iodine being the only element which gives the essential optical properties to the agent, large quantity of iodine is needed in preparing these compounds. Recently, graphene-based compounds are being researched for their exceptional optical properties, and their compatibility with the body tissues. If combined with iodine, they are believed to give a significant contrast with a less dose of the agent. In this thesis work, we tried to synthesize graphene nanoplatelets incorporating iodine ions through chemical bonding. We modified Hofmann's method1 to oxidize graphite flakes; with a further modification of using potassium iodate in the place of potassium chlorate as an oxidizer, in order to attach iodine ions to the graphene oxide platelets. Later, we reduced these oxidized graphene platelets using 32.1 mM hydroiodic acid instead of the standard hydrazine. Dextran-coating was done to make the molecules more dispersible in water and also biocompatible with the body tissues. The efficiency of the chemical reactions was examined by different characterization techniques like Raman Spectroscopy, UV-Vis spectroscopy and ISE. The morphology was checked by TEM and AFM. The particle size obtained was in the range of 1 - 2 µm. Cell toxicity studies were done by the LDH and Prestoblue assay to evaluate the toxicity of the particles on two different cell lines. CT Phantom studies showed that the contrast produced by the composite material was more than an equivalent amount of pure iodine. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Biomedical engineering en_US
dc.title Development of Iodinated Graphene Nanoplatelets through Redox Reaction for their Use as CT Contrast Agents en_US
dc.type Thesis en_US
dc.mimetype Application/PDF en_US

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