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Characterizing the lipoproteins LprG and LprA towards a better understanding of lipid transport mechanisms in Mycobacterium tuberculosis

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dc.contributor.advisor Seeliger, Jessica en_US
dc.contributor.advisor Tonge, Peter en_US
dc.contributor.author Bai, Lu en_US
dc.contributor.other Department of Chemistry en_US
dc.date.accessioned 2017-09-20T16:51:55Z
dc.date.available 2017-09-20T16:51:55Z
dc.date.issued 2013-12-01 en_US
dc.identifier.uri http://hdl.handle.net/11401/77086 en_US
dc.description 46 pgs en_US
dc.description.abstract Two lipoproteins, MtbLprG and MtbLprA, have been characterized as TLR2 agonists. Knockout of the lprG operon (lprG-rv1410c) results in decreased virulence of M. tb. While their importance for host-pathogen interactions has been the subject of numerous studies, the physiological functions of LprG and LprA are not known. We present here data towards elucidating the physiological functions of LprG and LprA, both in M. tb and M. smegmatis, including localization, binding affinity to respective ligands, as well as the phenotype of knockout strains, which will contribute a model for lipid transport through the cell wall. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Chemistry en_US
dc.title Characterizing the lipoproteins LprG and LprA towards a better understanding of lipid transport mechanisms in Mycobacterium tuberculosis en_US
dc.type Thesis en_US
dc.mimetype Application/PDF en_US
dc.contributor.committeemember London, Erwin en_US


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