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Genetic Contributions to Susceptibility and Resistance to Learned Helplessness

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dc.contributor.advisor Henn, Fritz A en_US
dc.contributor.author Garafola, Craig Scott en_US
dc.contributor.other Department of Genetics. en_US
dc.date.accessioned 2017-09-20T16:53:04Z
dc.date.available 2017-09-20T16:53:04Z
dc.date.issued 2014-12-01 en_US
dc.identifier.uri http://hdl.handle.net/11401/77625 en_US
dc.description 87 pg. en_US
dc.description.abstract Depression is a disease with a complex etiology that is only beginning to be studied from a genetic perspective. A selectively bred line of rats, susceptible to the learned helplessness model of depression, presents an opportunity to search for genes affecting either the depressive symptoms or the predisposition towards developing the disease. A microarray revealed a small set of genes with altered expression in the hippocampus of the congenitally helpless rats. We selected one of these genes, a member of the γ -protocadherin family, for further study to determine the basis for the change in expression. Helpless animals demonstrated an increased expression of protocadherin gamma A11, primarily in CA1 neurons. In addition, the helpless resistant line displayed changes in expression that favored a more excitotoxic state. Protocadherins have been implicated in synapse development and may alter the connections within the hippocampus in a way that enhances the correlates of depression found in other brain regions of the learned helpless rat. A greater understanding of the function of the clustered protocadherins in the establishment of neuronal networks is required to determine how these molecules affect the functional characteristics of the helpless brain. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree. en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Genetics en_US
dc.subject.other depression, hippocampus, learned helplessness, major depressive disorder, protocadherin en_US
dc.title Genetic Contributions to Susceptibility and Resistance to Learned Helplessness en_US
dc.type Dissertation en_US
dc.mimetype Application/PDF en_US
dc.contributor.committeemember Canli, Turhan en_US
dc.contributor.committeemember Aguirre, Adan en_US
dc.contributor.committeemember Li, Bo en_US
dc.contributor.committeemember Peña, Louis. en_US

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