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Layer and Cell Type Specific Functional Properties of Gustatory Cortex Neurons

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dc.contributor.advisor Fontanini, Alfredo en_US
dc.contributor.advisor LaCamera, Giancarlo. en_US
dc.contributor.author Dikecligil, Gulce Nazli
dc.contributor.other Department of Neuroscience. en_US
dc.date.accessioned 2018-07-09T13:27:31Z
dc.date.available 2018-07-09T13:27:31Z
dc.date.issued 2017-08-01
dc.identifier Dikecligil_grad.sunysb_0771E_13423.pdf en_US
dc.identifier.uri http://hdl.handle.net/11401/78330
dc.description 88 pg. en_US
dc.description.abstract The primary gustatory cortex is the cortical region devoted to processing taste. The gustatory cortex receives a wide range of projections from brain regions involved in sensory, limbic and cognitive functions. The functional properties of gustatory cortical neurons reflect this complex anatomical connectivity, encoding taste, sensorimotor, hedonic and anticipatory components of taste stimuli. No study to date has addressed whether there are differences in the functional properties of cortical neurons belonging to distinct layers and cell types. To address this question, I have performed a series of experiments using tract tracing and extracellular electrophysiological methods in mice. I demonstrate that in licking animals, firing rates of gustatory cortex neurons are modulated prior to the arrival of taste stimuli and this pre-stimulus modulation is biased to deep layer inhibitory neurons. Furthermore, I show that neurons in deep and superficial layers have distinct firing rates at baseline and stimulus evoked epochs. In the stimulus-evoked period, licking activity structures the activity of gustatory cortex where a subset of pyramidal neurons shows precise action potential timing within the lick cycles. Finally, I show that neurons that display pre-stimulus modulations and licking rhythm dependent activity can encode taste information. Together, the work presented in this dissertation provides fundamental insights into the distinct functional properties of gustatory cortex neurons belonging to distinct lamina and cell types. en_US
dc.description.sponsorship This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree en_US
dc.format Monograph en_US
dc.format.medium Electronic Resource en_US
dc.format.mimetype Application/PDF en_US
dc.language.iso en_US en_US
dc.subject.lcsh Neurosciences en_US
dc.subject.other Cortex en_US
dc.subject.other Gustatory en_US
dc.subject.other inhibitory en_US
dc.subject.other Laminar en_US
dc.subject.other licking en_US
dc.subject.other pyramidal en_US
dc.title Layer and Cell Type Specific Functional Properties of Gustatory Cortex Neurons en_US
dc.type Dissertation en_US
dc.contributor.committeemember Role, Lorna en_US
dc.contributor.committeemember Shea, Steve en_US
dc.contributor.committeemember Laubach, Mark. en_US

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